Lingyi Sun

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N⁶-methyladenosine demethylase FTO

Joel D. W. Toh, Lingyi Sun, Lisa Z. M. Lau et al. · Chemical Science · 2014 · 117 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +14

Synthesis of pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors of thymidine phosphorylase

Lingyi Sun, Hriday Bera, Wai Keung Chui · European Journal of Medicinal Chemistry · 2013 · 61 citations · Full text

Life Sciences, Chemistry, Pharmacology +10

Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors

Lingyi Sun, Jiarong Li, Hriday Bera et al. · European Journal of Medicinal Chemistry · 2013 · 35 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

A structure–activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities

Hriday Bera, Bee Jen Tan, Lingyi Sun et al. · European Journal of Medicinal Chemistry · 2013 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: Synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II

Hriday Bera, Probir Kumar Ojha, Bee Jen Tan et al. · European Journal of Medicinal Chemistry · 2014 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15