James X. Chen

Cytosine methylation determines hot spots of DNA damage in the human  <i>P</i> 53 gene

Mikhail F. Denissenko, James X. Chen, Moon‐shong Tang et al. · Proceedings of the National Academy of Sciences · 1997 · 334 citations · Full text

Bpde Adduct Formation, Dna Damage, Epigenetic Change +21

Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots.

James X. Chen, Yi Zheng, Melissa West et al. · PubMed · 1998 · 148 citations

Chromatin, Genome Instability, Mutational Hot Spots +13

Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.

Moon Shong Tang, Suryanarayana V. Vulimiri, Aurora Viaje et al. · PubMed · 2000 · 42 citations

Tumor-initiating Activity, Possess -Caa-, Chemoprevention Strategy +19

Sequence Preference of 7,12-Dimethylbenz[<i>a</i>]anthracene-<i>syn</i>-diol Epoxide−DNA Binding in the Mouse H-<i>ras</i> Gene Detected by UvrABC Nucleases

James X. Chen, Annie Pao, Yi Zheng et al. · Biochemistry · 1996 · 15 citations

Mapping polycyclic aromatic hydrocarbon and aromatic amine-induced DNA damage in cancer-related genes at the sequence level

Moon‐shong Tang, Gerd P. Pfeifer, Mikhail F. Denissenko et al. · International Journal of Hygiene and Environmental Health · 2002 · 10 citations

Genome Instability, Dna Damage, Oncogenic Agent +10