Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents

Philippe Panchaud, Thierry Bruyère, A.-C. Blumstein, +12

Journal of Medicinal Chemistry

Bioorganic ChemistryAntimicrobial ChemotherapyPharmaceutical ChemistryIsoquinoline Ethyl UreasDrug Resistance +14

Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity

Jean‐Philippe Surivet, Cornelia Zumbrunn, Georg Rueedi, +16

Journal of Medicinal Chemistry

Medicinal ChemistryPotent Anti-gram-positive ActivityAnalog 49CMedicineCombination Therapy +11

Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria

Jean‐Philippe Surivet, Cornelia Zumbrunn, Thierry Bruyère, +13

Journal of Medicinal Chemistry

Bioorganic ChemistryAntibacterial ActivityNovel AntibioticsAntimicrobial ChemotherapyPharmaceutical Chemistry +15

Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria

Jean‐Philippe Surivet, Philippe Panchaud, Jean‐Luc Specklin, +20

Journal of Medicinal Chemistry

Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A

Hiromu Hattori, Joel Roesslein, Patrick Caspers, +5

Angewandte Chemie International Edition

Bioorganic ChemistryGlycobiologyAntimicrobial ChemotherapyBacterial PathogensPharmaceutical Chemistry +17

Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram Positive Activity and Improved Safety Profile

Jean‐Philippe Surivet, Cornelia Zumbrunn, Georg Rueedi, +21

Journal of Medicinal Chemistry

Compound 32DAntibiotic AdjuvantChemical BiologyPharmaceutical ChemistryTopoisomerase Iv Inhibitors +14

Electrophile, Substrate Functionality, and Catalyst Effects in the Synthesis of α‐Mono and Di‐Substituted Benzylamines via Visible‐Light Photoredox Catalysis in Flow

Gianvito Vilé, Sylvia Richard‐Bildstein, Arnaud Lhuillery, +1

ChemCatChem

EngineeringSynthetic PhotochemistryOrganic ChemistryAvailable α‐Amino AcidsChemistry +14

Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic

Alain Scaiola, Marc Leibundgut, Daniel Boehringer, +5

Scientific Reports

Optimization of LpxC Inhibitor Lead Compounds Focusing on Efficacy and Formulation for High Dose Intravenous Administration

Philippe Panchaud, Jean‐Philippe Surivet, Stefan Diethelm, +16

Journal of Medicinal Chemistry

Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A

Hiromu Hattori, Joel Roesslein, Patrick Caspers, +5

Angewandte Chemie

Bioorganic ChemistryGlycobiologyAntimicrobial ChemotherapyBacterial PathogensPharmaceutical Chemistry +16