Philip J. Y. Leung

Robust deep learning–based protein sequence design using ProteinMPNN

Justas Dauparas, Ivan Anishchenko, Nathaniel R. Bennett et al. · Science · 2022 · 1.9K citations · Full text

Life Sciences, Biochemistry, Bioinformatics +14

De novo design of high-affinity binders of bioactive helical peptides

Susana Vázquez Torres, Philip J. Y. Leung, Preetham Venkatesh et al. · Nature · 2023 · 224 citations · Full text

Life Sciences, Bioengineering, Molecular Biology +15

Atomically accurate de novo design of antibodies with RFdiffusion

Nathaniel R. Bennett, Joseph L. Watson, Robert J. Ragotte et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2024 · 187 citations · Full text

Pharmacy, Immunology, Molecular Biology +17

Kinetic analysis of Cas12a and Cas13a RNA-Guided nucleases for development of improved CRISPR-Based diagnostics

Eric A. Nalefski, Nidhi Patel, Philip J. Y. Leung et al. · iScience · 2021 · 120 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +15

Robust deep learning based protein sequence design using ProteinMPNN

Justas Dauparas, Ivan Anishchenko, Nathaniel R. Bennett et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 118 citations · Full text

Life Sciences, Bioinformatics, Computational Biology +13