Anna Aparicio

ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment

Nicola J. Clegg, John Wongvipat, James D. Joseph et al. · Cancer Research · 2012 · 660 citations

Medicine, Oncology, Pharmacology +17

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

Andiliy Lai, Mehmet Kahraman, Steven P. Govek et al. · Journal of Medicinal Chemistry · 2015 · 247 citations · Full text

Medicine, Oncology, Pharmacology +13

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

James D. Joseph, Beatrice Darimont, Wei Zhou et al. · eLife · 2016 · 119 citations · Full text

Medicine, Oncology, Pharmacology +15

Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927

Mehmet Kahraman, Steven P. Govek, Johnny Nagasawa et al. · ACS Medicinal Chemistry Letters · 2018 · 76 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft

Steven P. Govek, Johnny Nagasawa, Karensa Douglas et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 46 citations

Medicine, Medicinal Chemistry, Oncology +14