Disease variant prediction with deep generative models of evolutionary data

Jonathan Frazer, Pascal Notin, Mafalda Dias, +5

Nature

Disease Variant PredictionGeneticsMedicineComputational BiologyGenerative Model +6

ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction

Pascal Notin, Aaron W. Kollasch, Daniel P. Ritter, +11

Inverse FoldingEngineeringMachine LearningMachine Learning ToolMolecular Biology +17

Tranception: protein fitness prediction with autoregressive transformers and inference-time retrieval

Pascal Notin, Mafalda Dias, Jonathan Frazer, +4

arXiv (Cornell University)

Multiplexed AssaysBiomolecular Structure PredictionGeneticsMolecular BiologyGenomics +18

23Na and 39K nuclear magnetic resonance studies of perfused rat hearts. Discrimination of intra- and extracellular ions using a shift reagent

Megan Pike, Jonathan Frazer, D.F. Dedrick, +4

Biophysical Journal

Cardiac MuscleExtracellular IonsPhysiologyIon ChannelsElectrophysiology +7

Chaotic inflation with kinetic alignment of axion fields

Thomas C. Bachlechner, Mafalda Dias, Jonathan Frazer, +1

Physical review. D. Particles, fields, gravitation, and cosmology/Physical review. D, Particles, fields, gravitation, and cosmology

Simple Predictions from Multifield Inflationary Models

Richard Easther, Jonathan Frazer, Hiranya V. Peiris, +1

Physical Review Letters

Monetary PolicyMultifield Inflationary ModelsSimple PredictionsEngineeringAlternative Cosmology +9

Multifield consequences for D-brane inflation

Mafalda Dias, Jonathan Frazer, Andrew R. Liddle

Journal of Cosmology and Astroparticle Physics

M-theoryEngineeringMultifield InflationPhysicsInflation (Cosmology) +8

Effect of erythrocyte storage and oxyhemoglobin affinity changes on cardiac function

Carl S. Apstein, R. C. Dennis, Laura E. Briggs, +3

American Journal of Physiology-Heart and Circulatory Physiology

Cardiac FunctionCardiac MuscleHigh Oha CellsOxyhemoglobin Affinity ChangesCardiovascular Function +14

MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays

Alan F. Rubin, Jeremy Stone, Aisha Haley Bianchi, +24

Genome biology

MULTIMODECODE: an efficient numerical solver for multifield inflation

Layne C. Price, Jonathan Frazer, Jiajun Xu, +2

Journal of Cosmology and Astroparticle Physics