Chlorogenic Acid and Synthetic Chlorogenic Acid Derivatives:  Novel Inhibitors of Hepatic Glucose-6-phosphate Translocase

Horst Hemmerle, Hans-Joerg Burger, Peter Below, +5

Journal of Medicinal Chemistry

Enzyme System Glucose-6-phosphatasePharmaceutical ChemistryLipid SynthesisBiochemistryMedicine +11

Chlorogenic Acid and Hydroxynitrobenzaldehyde: New Inhibitors of Hepatic Glucose 6-Phosphatase

William J. Arion, Wesley K. Canfield, Francis C. Ramos, +6

Archives of Biochemistry and Biophysics

A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds

Andrew M. Sawayama, Michael M. Y. Chen, Palaniappan Kulanthaivel, +3

Chemistry - A European Journal

Drug Lead DiversificationEngineeringMetabolomic ProfilingCytochrome P450 Bm3Drug Metabolites +15

A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century

Alexander G. Godfrey, Thierry Masquelin, Horst Hemmerle

Drug Discovery Today

Medicinal ChemistryDrug RepositioningEnable Drug DiscoveryInnovative ApproachMedicine +10

Pharmacodynamic profile of a novel inhibitor of the hepatic glucose-6-phosphatase system

Andreas W. Herling, Hans-Joerg Burger, Dietmar Schwab, +3

American Journal of Physiology-Gastrointestinal and Liver Physiology

Novel InhibitorMetabolic SyndromePharmacodynamic ProfileHepatotoxicityMetabolic State +15

Asymmetric hydrolysis, esterfication catalyzed by esterases from porcine pancreas in the synthesis of both enantiomers of cyclopentanoid building blocks

Horst Hemmerle, Hans‐Joachim Gais

Tetrahedron Letters

Asymmetric CatalysisBiosynthesisEngineeringBiochemistryAsymmetric Hydrolysis +9

Chlorogenic Acid Analogue S 3483: A Potent Competitive Inhibitor of the Hepatic and Renal Glucose-6-Phosphatase Systems

William J. Arion, Wesley K. Canfield, Francis C. Ramos, +6

Archives of Biochemistry and Biophysics

Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats

Andreas W. Herling, Hans-Joerg Burger, Gerrit Alexander Schubert, +3

European Journal of Pharmacology

Metabolic SyndromeEnergy MetabolismBiochemistryLipid MetabolismDiabetes +9

Identification, Synthesis, and Activity of Novel Blockers of the Voltage-Gated Potassium Channel Kv1.5

Stefan Peukert, Joachim Brendel, Bernard Pirard, +5

Journal of Medicinal Chemistry

Electrical EngineeringKv1.5 ChannelBiochemistryHyperpolarization (Biology)Medicine +11

Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet- and human-derived fatty acids

Fangyuan Chang, Piro Siuti, Stéphane Laurent, +6

Nature Microbiology

DysbiosisBiochemistryHuman-derived Fatty AcidsMedicineMicrobiota +6