A Novel Family of Negative and Positive Allosteric Modulators of NMDA Receptors

Blaise M. Costa, Mark W. Irvine, Guangyu Fang, +5

Journal of Pharmacology and Experimental Therapeutics

Different NMDA receptor subtypes mediate induction of long‐term potentiation and two forms of short‐term potentiation at CA1 synapses in rat hippocampus<i>in vitro</i>

Arturas Volianskis, Neil Bannister, Valerie J. Collett, +6

The Journal of Physiology

Rhodanine derivatives as novel inhibitors of PDE4

Mark W. Irvine, Graham L. Patrick, Justin Kewney, +2

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryRhodanine DerivativesDerivative (Chemistry)Medicine +4

N-Methyl-d-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat Hippocampal CA3-CA1 Synapse

Blaise M. Costa, Bihua Feng, Timur Tsintsadze, +6

Journal of Pharmacology and Experimental Therapeutics

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-d-aspartate receptors

Mark W. Irvine, Blaise M. Costa, Arturas Volianskis, +5

Neurochemistry International

Medicinal ChemistryCoumarin-3-carboxylic Acid DerivativesNative N-methyl-d-aspartate ReceptorsDrug DiscoveryMedicine +8

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

Grace France, Diego Fernández‐Fernández, Erica S. Burnell, +6

Neuropharmacology

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid

Blaise M. Costa, Mark W. Irvine, Guangyu Fang, +5

Neuropharmacology

Molecular DockingDrug TargetBiochemistryMedicineRational Drug Design +5

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Jue Xiang Wang, Mark W. Irvine, Erica S. Burnell, +9

Nature Communications

Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators

Grace France, Rasa Volianskis, Rachael Ingram, +16

Neuropharmacology

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators

Kiran Sapkota, Kim Doré, Kang Tang, +6

Biochemical Pharmacology

Molecular PharmacologyAllosteric ModulatorsMolecular NeuroscienceSignal TransductionMolecular Physiology +11