John F. Lyons

Two G Protein Oncogenes in Human Endocrine Tumors

John F. Lyons, Claudia A. Landis, Griffith Harsh et al. · Science · 1990 · 1K citations

Medicine, Genetics, Oncology +15

Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies

Jean‐Pierre J. Issa, Guillermo Garcia‐Manero, Francis J. Giles et al. · Blood · 2003 · 817 citations

Medicine, Oncology, Pharmacology +14

Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.

M. Jane Arboleda, John F. Lyons, Fairooz F. Kabbinavar et al. · PubMed · 2003 · 422 citations

Medicine, Cancer Biology, Oncology +17

High frequency of Ki‐<i>ras</i> codon 12 mutations in pancreatic adenocarcinomas

Kurt Grünewald, John F. Lyons, Anja Fröhlich et al. · International Journal of Cancer · 1989 · 290 citations

Medicine, Molecular Genetics, Oncology +16

Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines

Matthew Squires, Ruth E. Feltell, Nicola G. Wallis et al. · Molecular Cancer Therapeutics · 2009 · 172 citations

Medicine, Medicinal Chemistry, Oncology +15