Zhicai Shi

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

A. Buitrago Santanilla, Erik L. Regalado, Tony Pereira et al. · Science · 2014 · 649 citations

Pharmacy, Chemical Engineering, Chemistry +13

Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation

Charles E. Hendrick, Jeff R. Jorgensen, Charu Chaudhry et al. · ACS Medicinal Chemistry Letters · 2022 · 156 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +14

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

Jack D. Scott, Duane E. DeMong, Thomas J. Greshock et al. · Journal of Medicinal Chemistry · 2017 · 148 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Chemoselective Peptide Modification via Photocatalytic Tryptophan β-Position Conjugation

Younong Yu, Li‐Kang Zhang, Alexei V. Buevich et al. · Journal of the American Chemical Society · 2018 · 140 citations

Pharmacy, Biochemistry, Medicinal Chemistry +13

Profiling and Application of Photoredox C(sp³)–C(sp²) Cross-Coupling in Medicinal Chemistry

Rui Zhang, Guoqing Li, Michael K. Wismer et al. · ACS Medicinal Chemistry Letters · 2018 · 96 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +16