Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice

Hikari Takeshita, Kōichi Yamamoto, Satoko Nozato, +15

Scientific Reports

Muscle FunctionAgingKinesiologyMuscle InjurySkeletal Muscle +15

Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice

Masao Takeda, Kōichi Yamamoto, Yukihiro Takemura, +12

Diabetes

NutritionHypertensionCaloric RestrictionGlucose ToleranceInsulin Signaling +15

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

Tadashi Yamamuro, Tsuyoshi Kawabata, Atsunori Fukuhara, +12

Nature Communications

Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor

Kōichi Yamamoto, Akemi Kakino, Hikari Takeshita, +24

The FASEB Journal

At1 BlockadeCellular PhysiologyOxidative StressInflammationCell Signaling +15

Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging

Yingji Jin, Yoshito Takeda, Yasushi Kondo, +31

Scientific Reports

Angiotensin‐converting enzyme 2 deficiency accelerates and angiotensin 1‐7 restores age‐related muscle weakness in mice

Hikari Takeshita, Kōichi Yamamoto, Satoko Nozato, +23

Journal of Cachexia Sarcopenia and Muscle

Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice

Satoko Nozato, Kōichi Yamamoto, Hikari Takeshita, +14

Clinical Science

The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor

Toshimasa Takahashi, Yibin Huang, Kōichi Yamamoto, +21

iScience

Telmisartan modulates mitochondrial function in vascular smooth muscle cells

Kiyo Takeuchi, Kōichi Yamamoto, Mitsuru Ohishi, +7

Hypertension Research

Molecular PhysiologyMitochondrial FunctionPhysiologyVascular BiologyMedicine +3

Different effects of the deletion of angiotensin converting enzyme 2 and chronic activation of the renin-angiotensin system on muscle weakness in middle-aged mice

Hikari Takeshita, Kōichi Yamamoto, Masaki Mogi, +3

Hypertension Research

HypertensionMuscle WeaknessAgingChronic ActivationMedicine +6