Leena K. Satyam

A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy

Pottayil G. Sasikumar, Raghuveer Ramachandra, Srinivas Adurthi et al. · Molecular Cancer Therapeutics · 2019 · 63 citations · Full text

Medicine, Oncology, Pharmacology +17

Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors

Rajeev Goswami, Subhendu Mukherjee, Gerd Wohlfahrt et al. · ACS Medicinal Chemistry Letters · 2013 · 28 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

A novel peptide therapeutic targeting PD1 immune checkpoint with equipotent antagonism of both ligands and a potential for better management of immune-related adverse events

Pottayil G. Sasikumar, Rajeev Shrimali, Sreenivas Adurthi et al. · Journal for ImmunoTherapy of Cancer · 2013 · 19 citations · Full text

Medicine, Pharmacology, Cancer Pharmacology +13

Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy

Rajeev Goswami, Subhendu Mukherjee, Chakshusmathi Ghadiyaram et al. · Bioorganic & Medicinal Chemistry · 2014 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Abstract 2850: Demonstration of anti-tumor efficacy in multiple preclinical cancer models using a novel peptide inhibitor (Aurigene-012) of the PD1 signaling pathway

Pottayil G. Sasikumar, Leena K. Satyam, Rajeev Shrimali et al. · Cancer Research · 2012 · 13 citations

Medicine, Oncology, Pharmacology +17