Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

Masahiro Hosaka, Masami Nagahama, W.S. Kim, +5

Journal of Biological Chemistry

Protein SecretionMolecular BiologyArg-x-lys/arg-arg MotifProtein ExpressionProteomics +15

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

Kiyotaka Hatsuzawa, Masahiro Hosaka, Tsutomu Nakagawa, +4

Journal of Biological Chemistry

Molecular BiologyCellular PhysiologyProtein SynthesisProtein ExpressionKex2 Protease +16

Determinants of liposome fusion mediated by synaptic SNARE proteins

Christina G. Schuette, Kiyotaka Hatsuzawa, Martin Margittai, +6

Proceedings of the National Academy of Sciences

Membrane FusionProtein SecretionSignal TransductionCell SignalingNatural Sciences +12

Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi

Hidenori Hirose, Kohei Arasaki, Naoshi Dohmae, +7

The EMBO Journal

Golgi ApparatusMembrane TraffickingSecretory PathwayMolecular BiologyMembrane Biology +6

Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells.

Kiyotaka Hatsuzawa, Masami Nagahama, Shouji Takahashi, +3

Journal of Biological Chemistry

OocyteProtein SecretionMolecular BiologyCytoskeletonReproductive Biology +19

The R-SNARE Motif of Tomosyn Forms SNARE Core Complexes with Syntaxin 1 and SNAP-25 and Down-regulates Exocytosis

Kiyotaka Hatsuzawa, Thorsten Lang, Dirk Fasshauer, +2

Journal of Biological Chemistry

Evidence for involvement of furin in cleavage and activation of diphtheria toxin.

Makoto Tsuneoka, Kazuhisa Nakayama, Kiyotaka Hatsuzawa, +3

Journal of Biological Chemistry

ToxinologyImmunologyPathologyCytoskeletonCulture Medium +15

Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin

Masayuki Komada, Kiyotaka Hatsuzawa, Sayumi Shibamoto, +3

FEBS Letters

A Mutation of Furin Causes the Lack of Precursor-Processing Activity in Human Colon Carcinoma LoVo Cells

Shouji Takahashi, Kiyoto Kasai, Kiyotaka Hatsuzawa, +5

Biochemical and Biophysical Research Communications

Oncogenic AgentMedicineFurin CausesPathologyMolecular Pathology +6

Syntaxin 18, a SNAP Receptor That Functions in the Endoplasmic Reticulum, Intermediate Compartment, and cis-Golgi Vesicle Trafficking

Kiyotaka Hatsuzawa, Hidenori Hirose, Katsuko Tani, +3

Journal of Biological Chemistry