Phase variation in <i>Mycobacterium tuberculosis glpK</i> produces transiently heritable drug tolerance

Hassan Safi, Pooja Gopal, Subramanya Lingaraju, +14

Proceedings of the National Academy of Sciences

Pyrazinamide triggers degradation of its target aspartate decarboxylase

Pooja Gopal, Jickky Palmae Sarathy, Michelle Yee, +12

Nature Communications

Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis

Pooja Gopal, Michelle Yee, Jickky Palmae Sarathy, +6

ACS Infectious Diseases

Virulence PathwaysDistinct MechanismsBioorganic ChemistryBacteriologyMolecular Biology +19

Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States

Shuhui Lim, Regina Khoo, Yu‐Chi Juang, +8

ACS Central Science

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

Laura E. Via, Rada Savic, Matthew Zimmerman, +16

ACS Infectious Diseases

Antiparasitic AgentImmunologyPharmacotherapyPharmaceutical ChemistryLung Tissue +16

Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD

Pooja Gopal, Wilson Nartey, Priya Ragunathan, +8

ACS Infectious Diseases

BiosynthesisProdrug PyrazinamideBiochemistryCritical TuberculosisMedicine +12

Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis

Michelle Yee, Pooja Gopal, Thomas Dick

Antimicrobial Agents and Chemotherapy

Pulmonary TuberculosisProdrug PyrazinamideAntimicrobial Resistance GeneHealth SciencesMedicine +13

G9a mediates Sharp-1–dependent inhibition of skeletal muscle differentiation

Belinda Mei Tze Ling, Suma Gopinadhan, Wai Kay Kok, +5

Molecular Biology of the Cell

Histone ModificationsMuscle FunctionEpigenetic ChangeCytoskeletonEpigenetics +22

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37- <i>N</i> ¹ )-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism

Wenhe Zhong, Kalyan Kumar Pasunooti, Seetharamsing Balamkundu, +14

Journal of Medicinal Chemistry

In Vivo-Selected Pyrazinoic Acid-Resistant <i>Mycobacterium tuberculosis</i> Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1

Pooja Gopal, Rokeya Tasneen, Michelle Yee, +7

ACS Infectious Diseases

Tuberculosis PreventionMolecular BiologyAntimicrobial ChemotherapyDrug ResistanceMedical Microbiology +16