Tadafumi Tamura

Histamine H1 receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, Raf/MEK/ERK and IKK/IκB/NF-κB signal cascades

Masahiro Matsubara, Tadafumi Tamura, Kenji Ohmori et al. · Biochemical Pharmacology · 2004 · 132 citations

Life Sciences, Immunology, Pharmacology +14

Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption

Tadafumi Tamura, Tomomi Shirai, Nobuo Kosaka et al. · European Journal of Pharmacology · 2002 · 85 citations

Medicine, Pharmacology, Pharmacotherapy +16

A novel synthesis and potent antiinflammatory activity of 4-hydroxy-2(1H)-oxo-1-phenyl-1,8-naphthyridine-3-carboxamides

Takeshi Kuroda, Fumio Suzuki, Tadafumi Tamura et al. · Journal of Medicinal Chemistry · 1992 · 81 citations

Natural Sciences, Medicinal Chemistry, Pharmacology +7

Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes

Tadafumi Tamura, Nobuo Kosaka, JUN ISHIWA et al. · Osteoarthritis and Cartilage · 2001 · 70 citations · Full text

Life Sciences, Biochemistry, Cell Biology +10

Rhein, an Active Metabolite of Diacerein, Suppresses the Interleukin-1 α-Induced Proteoglycan Degradation in Cultured Rabbit Articular Chondrocytes

Tadafumi Tamura, Kenji Ohmori · The Japanese Journal of Pharmacology · 2001 · 55 citations · Full text

Medicine, Orthopaedic Surgery, Pharmacology +17