Structural Proof of a Dimeric Positive Modulator Bridging Two Identical AMPA Receptor-Binding Sites

Birgitte H. Kaae, Kasper Harpsøe, J.S. Kastrup, +8

Chemistry & Biology

Signal TransductionMolecular PhysiologyBiochemistryG Protein-coupled ReceptorNatural Sciences +8

Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection

Povl Krogsgaard‐Larsen, John W. Ferkany, Elsebet Ø. Nielsen, +7

Journal of Medicinal Chemistry

Design of excitatory amino acid receptor agonists, partial agonists and antagonists: ibotenic acid as a key lead structure

Povl Krogsgaard‐Larsen, Bjarke Ebert, Hans Bräuner‐Osborne, +3

European Journal of Medicinal Chemistry

Key Lead StructureBiochemistryFunctional SelectivityMedicineReceptor (Biochemistry) +7

Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA

Tine B. Stensbøl, Lars Borre, Tommy N. Johansen, +4

European Journal of Pharmacology

Molecular PharmacologyBiochemistryMedicineMechanism Of ActionExperimental Pharmacology +3

Partial Agonism and Antagonism of the Ionotropic Glutamate Receptor iGLuR5

Helle Hald, Peter Naur, Darryl S. Pickering, +9

Journal of Biological Chemistry

Conformational ChangesDomain OpeningChemical BiologyMedicinal ChemistryCell Signaling +15

(<i>S</i>)-Homo-AMPA, a Specific Agonist at the mGlu₆ Subtype of Metabotropic Glutamic Acid Receptors

Haleh Ahmadian, Birgitte Nielsen, Hans Bräuner‐Osborne, +7

Journal of Medicinal Chemistry

Rapid Synthesis of Aryl Azides from Aryl Halides under Mild Conditions

Xifu Liang, Jacob Andersen, Ulf Madsen, +1

Synlett

Catalyst SystemChemical EngineeringSodium AscorbateEngineeringMild Conditions +10

Novel 1-Hydroxyazole Bioisosteres of Glutamic Acid. Synthesis, Protolytic Properties, and Pharmacology

Tine B. Stensbøl, Peter Uhlmann, Sandrine Morel, +11

Journal of Medicinal Chemistry

Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors

Mette B. Hermit, Jeremy R. Greenwood, Birgitte Nielsen, +8

European Journal of Pharmacology

Thioibotenic AcidBiochemistryFunctional SelectivityMedicineReceptor (Biochemistry) +7

Bioisosteric Modifications of 2-Arylureidobenzoic Acids:  Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5

Jon Valgeirsson, Elsebet Ø. Nielsen, Dan Peters, +3

Journal of Medicinal Chemistry

Bioisosteric ModificationsGlur5 ReceptorsPharmacotherapyChemical BiologyPharmaceutical Chemistry +15