Antitumor Effects of a Combined 5-Aza-2′Deoxycytidine and Valproic Acid Treatment on Rhabdomyosarcoma and Medulloblastoma in <i>Ptch</i> Mutant Mice

Ines Ecke, Frauke Petry, Albert Rosenberger, +12

Cancer Research

Histone ModificationsEpigenetic ChangeValproic Acid TreatmentPathologyCancer Biology +19

The Hedgehog receptor Patched controls lymphoid lineage commitment

Anja Uhmann, Kai Dittmann, Frauke Nitzki, +12

Blood

Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway

Willemijn A. van Dop, Anja Uhmann, Mark Wijgerde, +9

Gastroenterology

Cell LineageDevelopmental BiologyMorphogenesisCell ProliferationGut Barrier +6

Antitumoral Effects of Calcitriol in Basal Cell Carcinomas Involve Inhibition of Hedgehog Signaling and Induction of Vitamin D Receptor Signaling and Differentiation

Anja Uhmann, Hannah Niemann, Bérénice Lammering, +14

Molecular Cancer Therapeutics

Tumor BiologyOncologyHedgehog SignalingSignaling PathwayChemoprevention Strategy +13

Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts

Arne Zibat, Anja Uhmann, Frauke Nitzki, +9

Carcinogenesis

Hedgehog signaling activation induces stem cell proliferation and hormone release in the adult pituitary gland

Joanna Pyczek, Rolf Buslei, David Schult, +5

Scientific Reports

Tumor Stroma–Derived Wnt5a Induces Differentiation of Basal Cell Carcinoma of <i>Ptch</i> -Mutant Mice via CaMKII

Frauke Nitzki, Arne Zibat, Simone König, +12

Cancer Research

A model for PTCH1/Ptch1-associated tumors comprising mutational inactivation and gene silencing.

Anja Uhmann, Uta Ferch, Regine Bauer, +6

PubMed

Cancer PathologyPtch1 PromoterPathologyEpigeneticsSonic Hedgehog +18

Inactivation of Patched1 in Mice Leads to Development of Gastrointestinal Stromal-Like Tumors That Express Pdgfrα but Not Kit

Penelope Pelczar, Arne Zibat, Willemijn A. van Dop, +21

Gastroenterology

Tumor BiologyMice LeadsMedicinePathologyCancer Cell Biology +7

Depletion of Cutaneous Macrophages and Dendritic Cells Promotes Growth of Basal Cell Carcinoma in Mice

Simone König, Frauke Nitzki, Anja Uhmann, +8

PLoS ONE

Cutaneous MacrophagesCutaneous BiologySignificant Bcc EnlargementMelanomaImmunology +11