Genetic determinants and epigenetic effects of pioneer-factor occupancy

Julie Donaghey, Sudhir Thakurela, Jocelyn Charlton, +14

Nature Genetics

Molecular EcologyGeneticsGenetic FactorEpigeneticsMedicine +2

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

Juan R. Alvarez‐Dominguez, Julie Donaghey, Niloofar Rasouli, +6

Cell stem cell

Developmental BiologyEndocrine MechanismMedicinePhysiologyHomeostatic Mechanism +5

Lin28 sustains early renal progenitors and induces Wilms tumor

Achia Urbach, Alena Yermalovich, Jin Zhang, +10

Genes & Development

Human Wilms TumorRenal PathologyRenal InflammationPathologyCancer Biology +16

Genome-wide tracking of dCas9-methyltransferase footprints

Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, +13

Nature Communications

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis

Bruno Di Stefano, En‐Ching Luo, Chuck Haggerty, +19

Cell stem cell

P-body HomeostasisMolecular RegulationNatural SciencesRna BiologyMolecular Biology +7

TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers

Jocelyn Charlton, Eunmi J. Jung, Alexandra L. Mattei, +11

Nature Genetics

Somatic EnhancersChromatinDnmt3 ActivityLineage PlasticityDevelopmental Biology +11

Global delay in nascent strand DNA methylation

Jocelyn Charlton, Timothy L. Downing, Zachary D. Smith, +12

Nature Structural & Molecular Biology

ChromatinGlobal DelayEpigenetic ChangeGeneticsDna Methylation +5

Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo

Justin Brumbaugh, Ik Soo Kim, Fei Ji, +14

Nature Cell Biology

Histone ModificationsChromatinChromatin RemodelingSite-specific Histone MethylationGenetics +12

Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling

Aurélia Huyghe, Giacomo Furlan, Duygu Ozmadenci, +20

Nature Cell Biology

Signal TransductionDevelopmental BiologySignaling PathwayReceptor Tyrosine KinaseUnc5b Co-regulation +5

Comparative methylome analysis identifies new tumour subtypes and biomarkers for transformation of nephrogenic rests into Wilms tumour

Jocelyn Charlton, Richard D. Williams, Neil J. Sebire, +9

Genome Medicine