Oranart Suntornwat

Total synthesis and evaluation of (.+-.)-N-(tert-butoxycarbonyl)-CBI, (.+-.)-CBI-CDPI1, and (.+-.)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunit

Dale L. Boger, Takayoshi Ishizaki, Ronald J. Wysocki et al. · Journal of the American Chemical Society · 1989 · 162 citations

Left-hand Subunit, Diversity Oriented Synthesis, Engineering +15

Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore

Dale L. Boger, Takayoshi Ishizaki, Hamideh Zarrinmayeh et al. · Journal of the American Chemical Society · 1990 · 136 citations

Pharmaceutical Science, Bioorganic Chemistry, Altmetric Attention Score +18

Synthesis of N-(tert-butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) left-hand subunit

Dale L. Boger, Takayoshi Ishizaki, Paul A. Kitos et al. · The Journal of Organic Chemistry · 1990 · 115 citations

Left-hand Subunit, Engineering, Heterocyclic +11

Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophore

Dale L. Boger, Takayoshi Ishizaki, Hamideh Zarrinmayeh et al. · The Journal of Organic Chemistry · 1990 · 93 citations

Pharmaceutical Science, Bioorganic Chemistry, Duocarmycin/pyrindamycin Alkylation Subunit +19

Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit.

Dale L. Boger, Hamideh Zarrinmayeh, S. A. MUNK et al. · Proceedings of the National Academy of Sciences · 1991 · 52 citations · Full text

Bioorganic Chemistry, Molecular Biology, Chemical Biology +20