Defeng Tian

Structure−Activity Relationship Studies of Ethyl 2-Amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4<i>H</i>-chromene-3-carboxylate (HA 14-1), an Antagonist for Antiapoptotic Bcl-2 Proteins To Overcome Drug Resistance in Cancer

Jignesh Doshi, Defeng Tian, Chengguo Xing · Journal of Medicinal Chemistry · 2006 · 116 citations · Full text

Chemoprevention Strategy, Binding Affinity, Cell Death +17

Structure−Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4<i>H</i>-chromene-3-carboxylate (sHA 14-1) and Its Analogues

Sonia G. Das, Jignesh Doshi, Defeng Tian et al. · Journal of Medicinal Chemistry · 2009 · 74 citations · Full text

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell

Defeng Tian, Sonia G. Das, Jignesh Doshi et al. · Cancer Letters · 2007 · 72 citations · Full text

Hematological Malignancy, Sha 14-1, Medicine +8

Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4<i>H</i>- chromene-3-carboxylate (HA 14-1), a Prototype Small-Molecule Antagonist against Antiapoptotic Bcl-2 Proteins, Decomposes To Generate Reactive Oxygen Species That Induce Apoptosis

Jignesh Doshi, Defeng Tian, Chengguo Xing · Molecular Pharmaceutics · 2007 · 44 citations

WL-276, an Antagonist against Bcl-2 Proteins, Overcomes Drug Resistance and Suppresses Prostate Tumor Growth

Liangyou Wang, Daniel T. Sloper, Sadiya N. Addo et al. · Cancer Research · 2008 · 36 citations · Full text