A Dramatic Increase of C1q Protein in the CNS during Normal Aging

Alexander Stephan, Daniel V. Madison, José Marı́a Mateos, +11

Journal of Neuroscience

C1q Protein LevelsSynapse EliminationC1q-deficient MiceImmunologyBiogerontology +23

Neurotrypsin cleaves agrin locally at the synapse

Alexander Stephan, José Marı́a Mateos, Serguei Kozlov, +7

The FASEB Journal

BiochemistryMedicineNatural SciencesNeurotransmitterMolecular Biology +11

Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA

Lingling Kong, David Valdivia, Christian M. Simon, +20

Science Translational Medicine

Risdiplam, the First Approved Small Molecule Splicing Modifier Drug as a Blueprint for Future Transformative Medicines

Hasane Ratni, R. Scalco, Alexander Stephan

ACS Medicinal Chemistry Letters

Rna ProcessingDrug RepositioningFuture Transformative MedicinesDrug TargetMedicine +13

Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction

Marc Bolliger, Andreas Zurlinden, Daniel Lüscher, +14

Journal of Cell Science

Subsequent Nmj MaturationSynaptic TransmissionMolecular BiologyPeripheral NervesCellular Neurobiology +24

Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation

Raymond Reif, Susanne Sales, Stefan Hettwer, +11

The FASEB Journal

Synaptic TransmissionNeurotransmitterMolecular BiologyCytoskeletonNeurotrypsin Suffer +18

Activity-Induced Synaptic Capture and Exocytosis of the Neuronal Serine Protease Neurotrypsin

Renato Frischknecht, Anna Fejtová, Miriam Viesti, +2

Journal of Neuroscience

Neurotrypsin VesiclesSynaptic TransmissionNeurotransmitterCytoskeletonNeurotransmission +19

Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3

Alexander Berg, Johan Zelano, Alexander Stephan, +5

Experimental Neurology

Synaptic PlasticityNeuroanatomySynaptic TransmissionMedicineSpinal Motoneurons +8

LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages

Alexander Stephan, Marina Batinica, Julia Steiger, +4

Immunology

Regulation of the Ligand-dependent Activation of the Epidermal Growth Factor Receptor by Calmodulin

Hongbing Li, Svetlana Panina, Amandeep Kaur, +7

Journal of Biological Chemistry