Exploring the Mechanical Behavior of Single Intermediate Filaments

Laurent Kreplak, Harald Bär, J.F. Leterrier, +2

Journal of Molecular Biology

Pattern FormationEngineeringMicromechanicsFiber StructureMechanics +7

Severe muscle disease-causing desmin mutations interfere with <i>in vitro</i> filament assembly at distinct stages

Harald Bär, Norbert Mücke, Anna Kostareva, +3

Proceedings of the National Academy of Sciences

Molecular BiologyCytoskeletonCellular PhysiologySkeletal MuscleMajor Intermediate Filament +15

Desmin and Vimentin Intermediate Filament Networks: Their Viscoelastic Properties Investigated by Mechanical Rheometry

Michael Schopferer, Harald Bär, Bernhard Hochstein, +4

Journal of Molecular Biology

Rheological Constitutive EquationRheological MeasurementMechanical RheometryEngineeringMechanical Properties +12

Conspicuous involvement of desmin tail mutations in diverse cardiac and skeletal myopathies

Harald Bär, Bertrand Goudeau, Sarah Wälde, +11

Human Mutation

Cardiac MuscleGeneticsIntermediate FilamentMolecular BiologyPathology +16

Pathogenic effects of a novel heterozygous R350P desmin mutation on the assembly of desmin intermediate filaments in vivo and in vitro

Harald Bär, Dirk Fischer, Bertrand Goudeau, +6

Human Molecular Genetics

GeneticsMolecular BiologyCytoskeletonMolecular GeneticsProtein Genetics +14

Cardiomyocyte Production in Mass Suspension Culture: Embryonic Stem Cells as a Source for Great Amounts of Functional Cardiomyocytes

Sylvia Niebruegge, Andrea Nehring, Harald Bär, +3

Tissue Engineering Part A

Tissue EngineeringEngineeringCardiac Progenitor CellsBiofabricationCell Culture +20

Impact of Disease Mutations on the Desmin Filament Assembly Process

Harald Bär, Norbert Mücke, Philippe Ringler, +5

Journal of Molecular Biology

Cell DivisionProtein FoldingGeneticsMolecular BiologyProtein Misfolding +6

Mutations in Desmin's Carboxy-Terminal “Tail” Domain Severely Modify Filament and Network Mechanics

Harald Bär, Michael Schopferer, Sarika Sharma, +4

Journal of Molecular Biology

Network MechanicsGeneticsMolecular BiologyGenetic MechanismMolecular Genetics +2

Clinical, genetic, and cardiac magnetic resonance imaging findings in primary desminopathies

Katharina Strach, Torsten Sommer, Christian Grohé, +13

Neuromuscular Disorders

Primary DesminopathiesCardiac Magnetic ResonanceCorticobasal DegenerationDegenerative DiseaseProgressive Supranuclear Palsy +4

Severe Myopathy Mutations Modify the Nanomechanics of Desmin Intermediate Filaments

Laurent Kreplak, Harald Bär

Journal of Molecular Biology

MechanobiologyEngineeringDesmin Intermediate FilamentsBiomechanicsMolecular Biology +7