Courtney J. Mycroft‐West

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

Courtney J. Mycroft‐West, Dunhao Su, Isabel Pagani et al. · Thrombosis and Haemostasis · 2020 · 346 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding

Courtney J. Mycroft‐West, Dunhao Su, Stefano Elli et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 230 citations

Life Sciences, Biochemistry, Molecular Biology +17

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction

Scott E. Guimond, Courtney J. Mycroft‐West, Neha S. Gandhi et al. · ACS Central Science · 2022 · 109 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations

Julia A. Tree, Jeremy E. Turnbull, Karen R. Buttigieg et al. · British Journal of Pharmacology · 2020 · 102 citations · Full text

Life Sciences, Immunology, Infectious Diseases +14

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin

Courtney J. Mycroft‐West, Dunhao Su, Isabel Pagani et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 93 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17