Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers

Hilla Solomon, Nathan Dinowitz, Ioannis S. Pateras, +14

Oncogene

Mutant P53MedicineStem CellsColorectal CancerCancer Cell Biology +12

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

Jessica K. Nelson, May Zaw Thin, Theodore Evan, +16

Nature Communications

GREM1 is required to maintain cellular heterogeneity in pancreatic cancer

Linxiang Lan, Theodore Evan, Huafu Li, +18

Nature

Tumor BiologyPancreatic CancerCellular HeterogeneityMedicinePathology +5

Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation

Noa Rivlin, Shir Katz, Maayan Doody, +8

Proceedings of the National Academy of Sciences

Mutant EscsCell SpecializationTumor BiologyMutant P53Conformational Shift +17

The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

Yoav Shetzer, Sivan Kagan, Gabriela Koifman, +16

Cell Death and Differentiation

Embryonic Stem CellGenome InstabilityLineage PlasticityP53 LossMedicine +7

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

Giuseppe Lonetto, Gabriela Koifman, Alon Silberman, +7

Cell Death and Differentiation

Mutant P53Tumor BiologyMitochondrial FunctionMitochondrial DynamicMedicine +13

High Throughput Analysis of Golgi Structure by Imaging Flow Cytometry

Inbal Wortzel, Gabriela Koifman, Varda Rotter, +2

Scientific Reports

A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells

Gabriela Koifman, Yoav Shetzer, Shay Eizenberger, +6

Cancer Research

PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation

Galit Shahaf, Noa Rotem‐Dai, Gabriela Koifman, +3

Experimental Cell Research

Signal TransductionMolecular PhysiologyNegative RegulatorSignaling PathwayReceptor Tyrosine Kinase +8

Coupling presentation of MHC class I peptides to constitutive activation of antigen-presenting cells through the product of a single gene

Gal Cafri, E. Amram, Gal Rinott, +7

International Immunology