Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities

Ron J. Keizer, Rob ter Heine, Adam Frymoyer, +3

CPT Pharmacometrics & Systems Pharmacology

Precision DosingModel-informed Precision DosingTranslational MedicineTherapeutic Drug MonitoringMedicine +11

Model-Informed Precision Dosing of Vancomycin in Hospitalized Children: Implementation and Adoption at an Academic Children’s Hospital

Adam Frymoyer, Hayden T. Schwenk, Yvonne Zorn, +7

Frontiers in Pharmacology

Genetic Variants in Transcription Factors Are Associated With the Pharmacokinetics and Pharmacodynamics of Metformin

Srijib Goswami, Sook Wah Yee, Sophie L. Stocker, +15

Clinical Pharmacology & Therapeutics

The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin

Jennifer Hibma, Arik A. Zur, Richard A. Castro, +10

Clinical Pharmacokinetics

Pharmacological StudyBiochemistryMedicineMechanism Of ActionPharmacotherapy +3

Individualized Empiric Vancomycin Dosing in Neonates Using a Model-Based Approach

Adam Frymoyer, Chris Stockmann, Adam L. Hersh, +2

Journal of the Pediatric Infectious Diseases Society

Continuous Learning in Model‐Informed Precision Dosing: A Case Study in Pediatric Dosing of Vancomycin

Jasmine H. Hughes, Dominic M. H. Tong, Sarah Scarpace Lucas, +3

Clinical Pharmacology & Therapeutics

Machine LearningModel‐informed Precision DosingPharmacotherapyPhysiologically-based Pharmacokinetic ModelingPharmacodynamic Modeling +18

PharmGKB summary

Srijib Goswami, Li Gong, Kathleen M. Giacomini, +2

Pharmacogenetics and Genomics

South Asian CultureEast Asian StudiesOrientalismRuss B.East Asian Languages +4

Assessment of a Model-Informed Precision Dosing Platform Use in Routine Clinical Care for Personalized Busulfan Therapy in the Pediatric Hematopoietic Cell Transplantation (HCT) Population

Praveen Shukla, Srijib Goswami, Ron J. Keizer, +4

Frontiers in Pharmacology

Clinical decision support for chemotherapy‐induced neutropenia using a hybrid pharmacodynamic/machine learning model

Jasmine H. Hughes, Dominic M. H. Tong, Vanessa Burns, +5

CPT Pharmacometrics & Systems Pharmacology

PrognosisPharmacotherapyPharmacodynamic ModelingComputational MedicineData Science +16

Bayesian clinical decision support-guided versus clinician-guided vancomycin dosing in attainment of targeted pharmacokinetic parameters in a paediatric population

David Hughes, Srijib Goswami, Ron J. Keizer, +2

Journal of Antimicrobial Chemotherapy