DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis

Linda M. Henricks, Carin A.T.C. Lunenburg, Femke M. de Man, +28

The Lancet Oncology

MedicineProspective Safety AnalysisCancer ManagementPharmacotherapyCancer Treatment +7

Pembrolizumab versus placebo as post-nephrectomy adjuvant therapy for clear cell renal cell carcinoma (KEYNOTE-564): 30-month follow-up analysis of a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Thomas Powles, Piotr Tomczak, Se Hoon Park, +226

The Lancet Oncology

Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells

Wendy Onstenk, Anieta M. Sieuwerts, Jaco Kraan, +15

European Urology

UrologyOncologyGenitourinary CancerMedicineCirculating Tumor Cells +6

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

Lisanne F. van Dessel, Job van Riet, Minke Smits, +18

Nature Communications

Clinical activity and tolerability of enzalutamide (MDV3100) in patients with metastatic, castration‐resistant prostate cancer who progress after docetaxel and abiraterone treatment

Sushil K. Badrising, Vincent van der Noort, Inge M. van Oort, +9

Cancer

Phase I Safety, Pharmacokinetics, and Inhibition of Src Activity Study of Saracatinib in Patients with Solid Tumors

José Baselga, Andrés Cervantes, Erika Martinelli, +9

Clinical Cancer Research

Generating human prostate cancer organoids from leukapheresis enriched circulating tumour cells

Lisanne Mout, Lisanne F. van Dessel, Jaco Kraan, +17

European Journal of Cancer

UrologyTumor HeterogeneityMedicineTumour CellsCell Proliferation +7

A cost analysis of upfront DPYD genotype–guided dose individualisation in fluoropyrimidine-based anticancer therapy

Linda M. Henricks, Carin A.T.C. Lunenburg, Femke M. de Man, +28

European Journal of Cancer

Upfront DpydMedicineMetronomic TherapyPharmacologyPharmacotherapy +6

Local NSAID Gel (Eltenac) in the Treatment of Osteoarthritis of the Knee: A double blind study comparing eltenac with oral diclofenac and placebo gel

Jerker Sandelin, Arsi Harilainen, Hans Crone, +3

Scandinavian Journal of Rheumatology

Double Blind StudyKnee JointAnti-inflammatoryPharmacologyChronic Musculoskeletal Condition +12

Dose-escalation models for combination phase I trials in oncology

Paul Hamberg, Mark J. Ratain, Emmanuel Lesaffre, +1

European Journal of Cancer

Adaptive RadiotherapyDose-escalation ModelsClinical Trial DesignMedicineRadiation Therapy Planning +4