Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

Anne Louise Hansen, Gregory J. Buchan, Michael Rühl, +26

Proceedings of the National Academy of Sciences

ImmunologyPathologyInflammationAntiviral Drug DevelopmentSting Palmitoylation +16

5-Lipoxygenase: Underappreciated Role of a Pro-Inflammatory Enzyme in Tumorigenesis

Dieter Steinhilber, Astrid Fischer, Julia Metzner, +4

Frontiers in Pharmacology

Chemoprevention StrategyLipid PeroxidationCell DeathTumor Cell ViabilityCancer Biology +18

Electrophilic Fatty Acid Species Inhibit 5-Lipoxygenase and Attenuate Sepsis-Induced Pulmonary Inflammation

Khader Awwad, Svenja D. Steinbrink, Timo Frömel, +11

Antioxidants and Redox Signaling

5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell–like Cells in Acute Myeloid Leukemia

Jessica Roos, Claudia Oancea, Maria Heinßmann, +11

Cancer Research

Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects <i>in vitro</i> and <i>in vivo</i> by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity

Jasmin Fettel, Benjamin Kühn, Nathalie Guillen, +13

The FASEB Journal

5-Lipoxygenase is a direct p53 target gene in humans

Bianca Gilbert, Khalil Ali Ahmad, Jessica Roos, +8

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

OxysterolAldehyde DehydrogenaseBiochemistryLipid PeroxidationMedicine +3

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells

A Romański, K. Schwarz, Maren Keller, +9

Cell Cycle

Progenitor CellsLeukemic StemMixed-phenotype Acute LeukemiaCell ProliferationCancer Biology +21

Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells

Benjamin Kühn, Camilla Brat, Jasmin Fettel, +14

Biochemical Pharmacology

Chemoprevention StrategyMitochondrial DysfunctionMedicineLipid PeroxidationPathology +7

Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

Isabelle V. Maucher, Michael Rühl, Simon B.M. Kretschmer, +18

Biochemical Pharmacology

Medicinal ChemistryOxysterolAldehyde DehydrogenaseBiochemistryNatural Sciences +10

Expression of &lt;i&gt;TCL1&lt;/i&gt; in Hematologic Disorders

Jessica Roos, I. Hennig, J Schwaller, +8

Pathobiology