CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Rubina Tuladhar, Yunku Yeu, John T. Piazza, +9

Nature Communications

Rna ProcessingOff-target EffectNatural SciencesGeneticsGenetic Engineering +10

SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

Veronica Novotny‐Diermayr, Kanda Sangthongpitag, Chang Hu, +14

Molecular Cancer Therapeutics

Liquid TumorsHigh Tumor ExposureOncologyBiochemistryMedicine +13

Highly Efficient Phosphoproteome Capture and Analysis from Urinary Extracellular Vesicles

Xiaofeng Wu, Li Li, Anton Iliuk, +1

Journal of Proteome Research

Renal PathologyMolecular BiologyExtracellular MicrovesiclesCytoskeletonPeptide Science +23

Multiphase coalescence mediates Hippo pathway activation

Li Wang, Kyungsuk Choi, Ting Su, +10

Cell

Signal TransductionDevelopmental BiologySignaling PathwayMolecular PathwayCellular Senescence +3

Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling

Leni S. Jacob, Xiaofeng Wu, Michael Dodge, +7

Science Signaling

Discovery of (2<i>E</i>)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1<i>H</i>-benzimidazol-5-yl}-<i>N</i>-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

Haishan Wang, Niefang Yu, Dizhong Chen, +24

Journal of Medicinal Chemistry

Exosomal miR-1228 From Cancer-Associated Fibroblasts Promotes Cell Migration and Invasion of Osteosarcoma by Directly Targeting SCAI

Jianwei Wang, Xiaofeng Wu, GU Xiao-juan, +1

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Osteosarcoma Cell MigrationOsteosarcoma TherapyDirectly Targeting ScaiMedicinePathology +11

Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification

Anton Iliuk, Xiaofeng Wu, Li Li, +4

Journal of Proteome Research

Proteinlipid InteractionBiological Mass SpectrometryExtracellular MicrovesiclesAnalytical UltracentrifugationProteomic Technology +15

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells

Ozlem Kulak, Hua Chen, Brody Holohan, +12

Molecular and Cellular Biology

Telomere Length MaintenanceMolecular RegulationCancer BiologyCellular PhysiologyTumor Biology +17

Analytical Pipeline for Discovery and Verification of Glycoproteins from Plasma-Derived Extracellular Vesicles as Breast Cancer Biomarkers

I‐Hsuan Chen, Hillary Andaluz Aguilar, Sebastian Juan Paez, +6

Analytical Chemistry

Analytical PipelineBreast OncologyGlycobiologyExtracellular MicrovesiclesPlasma-derived Extracellular Vesicles +19