Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease

Hu Zeng, Jiahao Huang, Haowen Zhou, +12

Nature Neuroscience

ChromatinNeurodegenerative DiseasesSitu MappingAlzheimer's DiseaseSingle Cell Sequencing +8

Spatial atlas of the mouse central nervous system at molecular resolution

Hailing Shi, Yichun He, Yiming Zhou, +17

Nature

Spatially resolved single-cell translatomics at molecular resolution

Hu Zeng, Jiahao Huang, Jingyi Ren, +10

Science

EngineeringMrna TranslationSpatial OmicsTrajectory AnalysisSingle Cell Sequencing +14

ClusterMap for multi-scale clustering analysis of spatial gene expression

Yichun He, Xin Tang, Jiahao Huang, +13

Nature Communications

Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

Hongyu Chen, Dangliang Liu, Jianting Guo, +11

Nature Biotechnology

Translation CapacityEngineeringNucleic Acid ChemistryNatural SciencesRna Biology +7

Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape

Jingyi Ren, Haowen Zhou, Hu Zeng, +17

Nature Methods

Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation

Hongyu Chen, Dangliang Liu, Abhishek Aditham, +8

Nature Biotechnology

Protein FoldingTopological DesignNatural SciencesRna Structure PredictionMolecular Biology +8

Chemically Modified mocRNAs for Highly Efficient Protein Expression in Mammalian Cells

Abhishek Aditham, Hailing Shi, Jianting Guo, +6

ACS Chemical Biology

Multimodal charting of molecular and functional cell states via in situ electro-sequencing

Qiang Li, Zuwan Lin, Ren Liu, +12

Cell

BioinformaticsMultimodal ChartingSitu Electro-sequencingFunctional GenomicsEngineering +10

Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse

Kojiro Matsumoto, Jiahao Huang, Navin Viswakarma, +8

Carcinogenesis