Simone Thomas

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Nimitha R. Mathew, Francis Baumgartner, Lukas M. Braun et al. · Nature Medicine · 2018 · 283 citations · Full text

Cell Therapy, Flt3-itd-mutant Leukemia Cells, Immunology +7

GLA/DRST real-world outcome analysis of CAR-T cell therapies for large B-cell lymphoma in Germany

Wolfgang Bethge, Peter Martus, Michael Schmitt et al. · Blood · 2022 · 210 citations · Full text

CAR T-cells targeting FLT3 have potent activity against FLT3−ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib

Hardikkumar Jetani, Irene García‐Cadenas, Thomas Nerreter et al. · Leukemia · 2018 · 183 citations

Car T-cells, Signal Transduction, Immunology +4

Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes

Andrea Cortese, Yi Zhu, Adriana Rebelo et al. · Nature Genetics · 2020 · 170 citations · Full text

Biallelic Mutations, Somatic Variant, Genetic Disorder +9

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

Martin Böttcher, Kathrin Renner, Raffaela S. Berger et al. · OncoImmunology · 2018 · 120 citations · Full text

Mixed-phenotype Acute Leukemia, Immunology, Metabolic Remodeling +26