Darren B. McAffee

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

Leah V. Sibener, Ricardo A. Fernandes, Elizabeth Motunrayo Kolawole et al. · Cell · 2018 · 315 citations · Full text

Signal Transduction, Adaptive Immune System, T-regulatory Cell +12

Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events

Jenny J. Lin, Shalini T. Low-Nam, Katherine N. Alfieri et al. · Science Signaling · 2019 · 94 citations

How the T cell signaling network processes information to discriminate between self and agonist ligands

Raman Ganti, Wan‐Lin Lo, Darren B. McAffee et al. · Proceedings of the National Academy of Sciences · 2020 · 61 citations · Full text

T-regulatory Cell, Immunology, Immunologic Mechanism +18

Discrete LAT condensates encode antigen information from single pMHC:TCR binding events

Darren B. McAffee, Mark K. O’Dair, Jenny J. Lin et al. · Nature Communications · 2022 · 56 citations · Full text

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

Deepti Karandur, Moitrayee Bhattacharyya, Zijie Xia et al. · eLife · 2020 · 37 citations · Full text