DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

Diane Crighton, Simon Wilkinson, Jim O’Prey, +7

Cell

Cell AutophagyMitophagyApoptosisAutophagyCell Death +6

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

Daniele Bergamaschi, Milena Gasco, Louise Hiller, +16

Cancer Cell

Tumor BiologyOncologyMedicineApoptosisCell Death +9

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

Chiara Gorrini, Massimo Squatrito, Chiara Luise, +18

Nature

ChromatinGenome InstabilityTumor BiologyOncogenic AgentMedicine +8

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53

Daniele Bergamaschi, Yardena Samuels, Alexandra Sullivan, +9

Nature Genetics

P53 Proline-rich RegionSignal TransductionSignaling PathwayProtein FunctionNatural Sciences +10

Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo

Alexandra Sullivan, Nelofer Syed, Milena Gasco, +8

Oncogene

Tumor BiologyTumor HeterogeneityMedicinePathologyCancer Genomics +5

Identification of CDK10 as an Important Determinant of Resistance to Endocrine Therapy for Breast Cancer

Elizabeth Iorns, Nicholas C. Turner, Richard Elliott, +7

Cancer Cell

Breast OncologyOncologyMedicineImportant DeterminantImmunology +8

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

Nelofer Syed, Julia Langer, Karolina Janczar, +11

Cell Death and Disease

MitophagyEpigenetic ChangeGeneticsArginine BiosynthesisCell Death +17

Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging

Michael D. Allen, Phuong Luong, Chantelle Hudson, +30

Cancer Research

Tumor BiologyUrologyOncologic ImagingPet ImagingGenitourinary Cancer +13

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis

Barbara Delage, Phuong Luong, L Maharaj, +16

Cell Death and Disease

MitophagyApoptosisImmunologyPathologyCell Death +17

Transcriptional silencing of Polo-like kinase 2<i>(SNK/PLK2)</i>is a frequent event in B-cell malignancies

Nelofer Syed, Paul J. Smith, Alexandra Sullivan, +10

Blood