21:T512,The inflammatory damage caused by thrombus formation and dissolution can increase the risk of thrombotic complications on top of cell death and organ dysfunction caused by thrombus itself. Therefore, a rapid and precise thrombolytic therapy strategy is in urgent need to effectively dissolve thrombus and resist oxidation simultaneously. In this study, Ce-UiO-66, a cerium-based metal-organic framework (Ce-MOF) with reactive oxygen species (ROS) scavenging properties, encapsulated by low-immunogenic mesenchymal stem cell membrane with inflammation-targeting properties, is used to construct a targeted nanomedicine Ce-UiO-CM. Ce-UiO-CM is applied in combination with external ultrasound stimulation for thrombolytic therapy in rat femoral artery. Ce-UiO-66 has abundant Ce (III)/Ce (IV) coupling sites that react with hydrogen peroxide (H₂O₂) to produce oxygen, exhibiting catalase (CAT) activity. The multi-cavity structure of Ce-UiO-66 can generate electron holes, and its pore channels can act as micro-reactors to further enhance its ROS scavenging capacity. Additionally, the porous structure of Ce-UiO-66 and the oxygen produced by its reaction with H₂O₂ may enhance the cavitation effects of ultrasound, thereby improving thrombolysis efficacy.22:T480,Hypoxia is a common feature of many diseases such as solid tumors. The measurement and imaging of oxygen (O₂) are extremely important for disease diagnosis and therapy evaluation. In this work, the afterglow/fluorescence dual-emissive ratiometric O₂ probe based on a photochemical reaction-based afterglow system is reported. The afterglow is highly sensitive to O₂ because the O₂ content is directly related to the ¹O₂ yield and eventually affects the afterglow intensity. The O₂-insensitive fluorescence of an emitter can serve as an internal reference. As the O₂ concentration changes from 0.08 to 18.5 mg L^-1, the ratio value shows a remarkable 53-fold increase. Compared with the intensity of a single peak, the ratiometric signal can eliminate the interference of the probe concentration to achieve higher accuracy. This afterglow/fluorescence dual-emissive ratiometric O₂ probe is successfully applied to hypoxia imaging in tumor-bearing mice, which may further promote the development of O₂ sensing in the biomedical field.

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