A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

Ying Yu, James C. Fuscoe, Chen Zhao, +30

Nature Communications

EngineeringTranscriptomics TechnologyOrgan DevelopmentGene Expression ProfilingRat Model +17

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction

Wenqian Zhang, Ying Yu, Falk Hertwig, +71

Genome Biology

Interpretable Drug Target Prediction Using Deep Neural Representation

Kyle Yingkai Gao, Achille Fokoue, Heng Luo, +3

Structured PredictionSystems BiologyEngineeringMachine LearningData Science +12

DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical–protein interactome

Heng Luo, Jian Chen, Leming Shi, +4

Nucleic Acids Research

Drug TargetEngineeringNew IndicationsSystems PharmacologyData Science +19

Predicting adverse drug reactions through interpretable deep learning framework

Sanjoy Kumer Dey, Heng Luo, Achille Fokoue, +2

BMC Bioinformatics

TNF-α/IFN-γ profile of HBV-specific CD4 T cells is associated with liver damage and viral clearance in chronic HBV infection

Haoliang Wang, Heng Luo, Xing Wan, +9

Journal of Hepatology

Tnf-α/ifn-γ ProfileViral PersistenceHepatologyChronic Hbv InfectionViral Hepatitis +10

Drug Repositioning for Diabetes Based on 'Omics' Data Mining

Ming Zhang, Heng Luo, Zhengrui Xi, +1

PLoS ONE

Diabetes ManagementDrug RepositioningEngineeringDrug TargetData Mining +13

Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study

Lun Yang, Jian Chen, Anil G. Jegga, +8

PLoS Computational Biology

Drug TargetPharmacotherapySystem PharmacologyAdverse Drug ReactionSystems Pharmacology +15

A collaborative filtering framework based on both local user similarity and global user similarity

Heng Luo, Changyong Niu, Ruimin Shen, +1

Machine Learning

Local User SimilarityGroup RecommendersEngineeringInformation RetrievalData Science +7

Molecular Docking to Identify Associations Between Drugs and Class I Human Leukocyte Antigens for Predicting Idiosyncratic Drug Reactions

Heng Luo, Tingting Du, Peng Zhou, +9

Combinatorial Chemistry & High Throughput Screening

Drug TargetImmunologyImmunotherapyDrug HypersensitivityMedicinal Chemistry +14