Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1

Frank Rosenbauer, Katharina Wagner, Jeffery L. Kutok, +6

Nature Genetics

Hematological MalignancyChromatinGraded ReductionMixed-phenotype Acute LeukemiaGenetics +8

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis

Gang Huang, Pu Zhang, Hideyo Hirai, +12

Nature Genetics

Adult Mouse HematopoiesisMedicineHematologyBlood CellPathology +5

Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element

Yutaka Okuno, Gang Huang, Frank Rosenbauer, +9

Molecular and Cellular Biology

Molecular RegulationGeneticsImmunologyReporter GeneGene Regulatory Network +14

PDK1 inhibition is a novel therapeutic target in multiple myeloma

Saori Fujiwara, Yawara Kawano, Hiromichi Yuki, +4

British Journal of Cancer

An IL‐27/Stat3 axis induces expression of programmed cell death 1 ligands (<scp>PD</scp>‐L1/2) on infiltrating macrophages in lymphoma

Hasita Horlad, Chaoya Ma, Hiromu Yano, +9

Cancer Science

Multiple myeloma cells expressing low levels of CD138 have an immature phenotype and reduced sensitivity to lenalidomide

Yawara Kawano, Shiho Fujiwara, Naoko Wada, +8

International Journal of Oncology

Hematological MalignancyTumor BiologyPlasma CellsLow LevelsMedicine +12

Regulation of the PU.1 gene by distal elements

Youlin Li, Yutaka Okuno, Pu Zhang, +8

Blood

Differential regulation of the human and murine CD34 genes in hematopoietic stem cells

Yutaka Okuno, Hiromi Iwasaki, Claudia S. Huettner, +4

Proceedings of the National Academy of Sciences

Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells

Naoko Wada, Yawara Kawano, Shiho Fujiwara, +12

International Journal of Oncology

Necroptosis InducerMw 288.3ApoptosisPathologyCell Death +16

Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells

Miki Nakamura, Tomomi Gotoh, Yutaka Okuno, +6

Leukemia & lymphoma/Leukemia and lymphoma

ApoptosisImmunologyCell DeathCellular PhysiologyTumor Biology +17