Alexandra Coomans de Brachène

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Laura Marroquí, Reinaldo S. Dos Santos, Anne Op De Beeck et al. · Diabetologia · 2017 · 190 citations · Full text

Inflammation, Disease Mechanism, Apoptosis +10

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

Máikel L. Colli, Jessica L. Hill, Laura Marroquí et al. · EBioMedicine · 2018 · 181 citations · Full text

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

Máikel L. Colli, Mireia Ramos-Rodríguez, Ernesto Nakayasu et al. · Nature Communications · 2020 · 132 citations · Full text

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

Alexandra Coomans de Brachène, Reinaldo S. Dos Santos, Laura Marroquí et al. · Diabetologia · 2018 · 73 citations · Full text

Signal Transduction, Molecular Physiology, Ifn-α Induces +11

Interferons are key cytokines acting on pancreatic islets in type 1 diabetes

Alexandra Coomans de Brachène, Maria Inês Alvelos, Florian Szymczak et al. · Diabetologia · 2024 · 48 citations · Full text

Inflammation, Type 1, Islet Transplantation +12