Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells

Rae Record, Larry L. Froelich, Chris J. Vlahos, +1

American Journal of Physiology-Endocrinology and Metabolism

Cellular PhysiologyPp70 S6 KinaseInsulin SignalingSignaling PathwayReceptor Tyrosine Kinase +19

Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists

William T. Jackson, Robert J. Boyd, Larry L. Froelich, +3

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryFunctional SelectivityCompound 32Medicine +12

Pharmacologic Actions of the Second-Generation Leukotriene B4 Receptor Antagonist LY293111: In Vitro Studies

William T. Jackson, Larry L. Froelich, Robert J. Boyd, +11

Journal of Pharmacology and Experimental Therapeutics

Blockade of human neutrophil activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid (LY293111), a novel leukotriene B4 receptor antagonist

Philip Marder, J. Scott Sawyer, Larry L. Froelich, +2

Biochemical Pharmacology

InflammationAnti-inflammatoryBenzoic AcidGranulocyteMedicine +6

Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones

David K. Herron, Theodore Goodson, Nancy G. Bollinger, +6

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryHuman PmnBiochemistryMedicine +11

Structure-Based Design of Potent, Amidine-Derived Inhibitors of Factor Xa:  Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity

Michael R. Wiley, Leonard C. Weir, Steven L. Briggs, +26

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyAmidine-derived InhibitorsChemical BiologyPharmaceutical Chemistry +18

Synthetic and Structure/Activity Studies on Acid-Substituted 2-Arylphenols: Discovery of 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]- propoxy]phenoxy]benzoic Acid, a High-Affinity Leukotriene B4 Receptor Antagonist

J. Scott Sawyer, Nicholas J. Bach, Stephen Baker, +6

Journal of Medicinal Chemistry

Structural DerivativesMedicinal ChemistryPharmaceutical SciencePolyphenolicsBiochemistry +10

Non-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potent Anticoagulant and Antithrombotic Activity

John J. Masters, Jeffry B. Franciskovich, Jennifer M. Tinsley, +18

Journal of Medicinal Chemistry

Altmetric Attention ScorePharmacotherapyTranslational PharmacologyPre-clinical PharmacologyThrombosis +17

Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain

D. Mark Gapinski, Barbara E. Mallett, Larry L. Froelich, +1

Journal of Medicinal Chemistry

Pharmaceutical ScienceLeukotriene B4Para IsomerChemical BiologyPharmaceutical Chemistry +14

Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982.

William T. Jackson, Russell J. Boyd, Larry L. Froelich, +2

Journal of Pharmacology and Experimental Therapeutics