Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

Tao Pang, Zhenshan Zhang, Min Gu, +8

Journal of Biological Chemistry

Molecular BiologyAlpha SubunitsCellular PhysiologyInsulin SignalingSignaling Pathway +17

Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers.

Thomas W. Kensler, Xia He, Monicah A. Otieno, +22

PubMed

Chemoprevention StrategySerum AflatoxinPharmacotherapyFood ToxicologyOltipraz Chemoprevention Trial +20

Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against <i>Mycobacterium tuberculosis</i>

Wei Zhang, Shichun Lun, Shu-Huan Wang, +8

Journal of Medicinal Chemistry

Tuberculosis PreventionPks13 GeneChemical BiologyPharmaceutical ChemistryPolyketide Synthase 13 +17

1H NMR-based metabolomic analysis for identifying serum biomarkers to evaluate methotrexate treatment in patients with early rheumatoid arthritis

Zhigang Wang, Zhe Chen, Sisi Yang, +6

Experimental and Therapeutic Medicine

Metabolomic ProfilingEarly Rheumatoid ArthritisPsoriatic ArthritisRheumatoid DisorderBiomarker (Medicine) +19

Discovery of Isoxazole Analogues of Sazetidine-A as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists for the Treatment of Depression

Jianhua Liu, Li-Fang Yu, J. Brek Eaton, +11

Journal of Medicinal Chemistry

Monoamine TransportersPsychotropic MedicationNeurotransmitterPsychopharmacologyPharmacotherapy +18

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators

Li-Fang Yu, Yuanyuan Li, Mingbo Su, +9

ACS Medicinal Chemistry Letters

Chemical BiologyGlucose TolerancePharmaceutical ChemistryInsulin SignalingMolecular Pharmacology +19

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

Yuanyuan Li, Li-Fang Yu, Lína Zhang, +12

Toxicology and Applied Pharmacology

Signal TransductionBeneficial EffectsMedicineInsulin ManagementDiabetes +8

AICAR Induces Astroglial Differentiation of Neural Stem Cells via Activating the JAK/STAT3 Pathway Independently of AMP-activated Protein Kinase

Yi Zang, Li-Fang Yu, Tao Pang, +6

Journal of Biological Chemistry

Cerebral OrganoidCellular NeurobiologyGliomaSocial SciencesJak/stat3 Pathway Independently +21

The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives

Jing Wang, Teng Yang, Chenyang Huang, +8

European Journal of Medicinal Chemistry

13-Disubstituted Berberine DerivativesBioorganic ChemistryBiochemistryNatural SciencesStereoselective Synthesis +3

An inherently kidney-targeting near-infrared fluorophore based probe for early detection of acute kidney injury

Fangqin Wang, Xuefeng Jiang, Huaijiang Xiang, +10

Biosensors and Bioelectronics

EngineeringBiomedical DiagnosticsKidney FailureBiomedical ImagingKidney-targeting Near-infrared Fluorophore +8