Combinatorial Antiangiogenic Gene Therapy by Nonviral Gene Transfer Using the Sleeping Beauty Transposon Causes Tumor Regression and Improves Survival in Mice Bearing Intracranial Human Glioblastoma

John R. Ohlfest, Zachary L. Demorest, Yasuhiko Motooka, +9

Molecular Therapy

Cell TherapyNonviral Gene TransferHigh-grade GliomasBiomedical EngineeringGlioma +18

Persistence of CD133 ⁺ Cells in Human and Mouse Glioma Cell Lines: Detailed Characterization of GL261 Glioma Cells with Cancer Stem Cell-Like Properties

Anhua Wu, Seunguk Oh, Stephen M. Wiesner, +6

Stem Cells and Development

Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression

Amy P.N. Skubitz, Elizabeth Taras, Kristin L.M. Boylan, +4

Gynecologic Oncology

OncologyMedicineGynecologyTumor SuppressorCancer Treatment +6

Targeting Tumor-Initiating Cancer Cells with dCD133KDEL Shows Impressive Tumor Reductions in a Xenotransplant Model of Human Head and Neck Cancer

Nate N. Waldron, Dan S. Kaufman, Seunguk Oh, +4

Molecular Cancer Therapeutics

Xenotransplant ModelImmunologyImmunotherapyCancer BiologyTumor Biology +16

In Vivo Vaccination With Tumor Cell Lysate Plus CpG Oligodeoxynucleotides Eradicates Murine Glioblastoma

Anhua Wu, Seunguk Oh, Soheila Gharagozlou, +5

Journal of Immunotherapy

Transposon-based interferon gamma gene transfer overcomes limitations of episomal plasmid for immunogene therapy of glioblastoma

Anhua Wu, Seunguk Oh, Katya Ericson, +6

Cancer Gene Therapy

Neuro-oncologyImmunogene TherapyGliomaImmunologyGene Vector +6

Bioengineering a Unique Deimmunized Bispecific Targeted Toxin That Simultaneously Recognizes Human CD22 and CD19 Receptors in a Mouse Model of B-Cell Metastases

Daniel A. Vallera, Seunguk Oh, Hua Chen, +2

Molecular Cancer Therapeutics

ImmunologyB LymphomaBiological TherapyImmunotherapySynthetic Immunology +15

A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature

Alexander K. Tsai, Seunguk Oh, Hua Chen, +3

Journal of Neuro-Oncology

Drug TargetingMedicineHuman Glioblastoma CellsTumor NeovasculatureTumor Targeting +7

Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery

Seunguk Oh, John R. Ohlfest, D.A. Todhunter, +4

Journal of Neuro-Oncology

Nude RatsNeuro-oncologyCell-based Drug DeliveryDrug TargetingIntracranial Elimination +10

Efficacy of nonviral gene transfer in the canine brain

Seunguk Oh, G. Elizabeth Pluhar, Elizabeth McNeil, +6

Journal of neurosurgery