Luc Bertin

Discovery of (2<i>S</i>)-8-[(3<i>R</i>)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2<i>H</i>-pyrimido[1,2-<i>a</i>]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

Benoit Pasquier, Youssef El‐Ahmad, Bruno Filoche-Rommé et al. · Journal of Medicinal Chemistry · 2014 · 92 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers

Victor Certal, Jean‐Christophe Carry, Frank Halley et al. · Journal of Medicinal Chemistry · 2014 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3<i>S</i>)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7<i>H</i>-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer

Youssef El‐Ahmad, Michel Tabart, Frank Halley et al. · Journal of Medicinal Chemistry · 2019 · 81 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-<i>c</i>]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone

François Vallée, Chantal Carrez, Fabienne Pilorge et al. · Journal of Medicinal Chemistry · 2011 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Optimization and Gram-Scale Preparation of <i>S</i>-Trifluoromethyl Sulfoximines and Sulfilimino Iminiums, Powerful Reagents for the Late Stage Introduction of the CF₃ Group

Anne‐Laure Barthelemy, Victor Certal, Guillaume Dagousset et al. · Organic Process Research & Development · 2019 · 14 citations

Natural Sciences, Chemistry, Analytical Chemistry +4