A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, +121

Nature

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Mehdi Bouhaddou, Danish Memon, Bjoern Meyer, +74

Cell

Global Phosphorylation LandscapeViral PathogenesisVirologyViral Structural ProteinMedicine +1

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David E. Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, +95

The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

Catherine L. Grimes, Lushanti De Zoysa Ariyananda, James E. Melnyk, +1

Journal of the American Chemical Society

Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2

James E. Melnyk, Vishnu Mohanan, Amy K. Schaefer, +2

Journal of the American Chemical Society

Natural LigandsNod2 ResponsePeptidoglycan Modifications TuneMedicinePeptoid +12

Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets

Kelsey M. Haas, Michael McGregor, Mehdi Bouhaddou, +52

Nature Communications

The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells

James E. Melnyk, Veronica Steri, Hao G. Nguyen, +3

Bioorganic & Medicinal Chemistry

Androgen ReceptorUrologyOncologyFactor Rbm39Medicine +8

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

Ann‐Kathrin Reuschl, Lucy Thorne, Lorena Zuliani‐Alvarez, +20

Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2

Amy K. Schaefer, James E. Melnyk, Michael M. Baksh, +3

ACS Chemical Biology

Natural EnvironmentMicrobial PathogensInnate Immune SystemImmunologyImmune Regulation +20

Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCβ1

James E. Melnyk, Veronica Steri, Hao G. Nguyen, +5

Oncogene