Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19

Minchen Chien, Thomas K. Anderson, Steffen Jockusch, +6

Journal of Proteome Research

MedicineFurther Polymerase ExtensionImmunologyKey Drug TargetAntiviral Drug Development +10

Real-time single-molecule electronic DNA sequencing by synthesis using polymer-tagged nucleotides on a nanopore array

Carl W. Fuller, Shiv Kumar, Mintu Porel, +29

Proceedings of the National Academy of Sciences

A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19

Steffen Jockusch, Chuanjuan Tao, Xiaoxu Li, +6

Antiviral Research

Viral ReplicationNatural SciencesMolecular BiologyDna ReplicationVirology +6

PEG-Labeled Nucleotides and Nanopore Detection for Single Molecule DNASequencing by Synthesis

Shiv Kumar, Chuanjuan Tao, Minchen Chien, +8

Scientific Reports

<i>In vitro</i> antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19

Carolina Q. Sacramento, Natalia Fintelman‐Rodrigues, Jairo R. Temerozo, +37

Journal of Antimicrobial Chemotherapy

Nucleotide analogues as inhibitors of SARS‐CoV Polymerase

Jingyue Ju, Xiaoxu Li, Shiv Kumar, +7

Pharmacology Research & Perspectives

Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir

Steffen Jockusch, Chuanjuan Tao, Xiaoxu Li, +6

Scientific Reports

Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture

Xuanting Wang, Carolina Q. Sacramento, Steffen Jockusch, +16

Communications Biology

Design and characterization of a nanopore-coupled polymerase for single-molecule DNA sequencing by synthesis on an electrode array

P. Benjamin Stranges, Mirkó Palla, Sergey Kalachikov, +27

Proceedings of the National Academy of Sciences

Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase

Minchen Chien, Thomas K. Anderson, Steffen Jockusch, +6