Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Zhenming Jin, Xiaoyu Du, Yechun Xu, +28

Nature

MedicineAntiviral Drug DevelopmentChemistryViral Structural ProteinPharmacology +3

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Yan Gao, Liming Yan, Yucen Huang, +25

Science

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai, Bing Zhang, Xia-Ming Jiang, +24

Science

Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase

Quan Wang, Jiqin Wu, Haofeng Wang, +23

Cell

Viral ReplicationRna ReplicationViral Polymerase StructureRna Structure PredictionMolecular Biology +2

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

Zhenming Jin, Yao Zhao, Yuan Sun, +18

Nature Structural & Molecular Biology

Antineoplastic Drug CarmofurAntiviral CompoundBiochemistryMedicineAntiviral Drug Development +7

Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target

Bing Zhang, Jun Li, Xiaolin Yang, +14

Cell

Membrane StructureEngineeringBiochemistryMedicineMembrane Transport +7

An electron transfer path connects subunits of a mycobacterial respiratory supercomplex

Hongri Gong, Jun Li, Ao Xu, +23

Science

Structure of M ^pro from COVID-19 virus and discovery of its inhibitors

Zhenming Jin, Xiaoyu Du, Yechun Xu, +28

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol

Lu Zhang, Yao Zhao, Yan Gao, +24

Science

Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir

Yinkai Duan, Hao Zhou, Xiang Liu, +21

Nature

Sars-cov-2 ResistanceAntiviral Drug DevelopmentVirologyAntiviral DrugViral Structural Protein +2