The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Sohrab P. Shah, Andrew Roth, Rodrigo Goya, +56

Nature

Breast OncologyTumor HeterogeneityMedicinePathologyCancer Genomics +8

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

Hong Xu, Marco Di Antonio, Steven McKinney, +36

Nature Communications

Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling

Allen W. Zhang, Ciara H. O’Flanagan, Elizabeth A. Chavez, +19

Nature Methods

Functional GenomicsTumor HeterogeneityMedicineSingle Cell SequencingProbabilistic Cell-type Assignment +9

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

Allen W. Zhang, Andrew McPherson, Katy Milne, +42

Cell

Malignant DiseaseTumor HeterogeneityMedicineGynecologyRadiation Oncology +7

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Daisuke Ennishi, Katsuyoshi Takata, Wendy Béguelin, +23

Cancer Discovery

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

Emma Laks, Andrew McPherson, Hans Zahn, +43

Cell

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

Gavin Ha, Andrew Roth, Daniel Lai, +14

Genome Research

Breast OncologyGeneticsTranscriptomics TechnologyIntegrative AnalysisTumor Biology +14

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes

Yi Kan Wang, Ali Bashashati, Michael S. Anglesio, +33

Nature Genetics

Genome InstabilityGenomic ConsequencesSomatic VariantGeneticsOvarian Cancer Histotypes +6

Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment

Laura Kuett, Raúl Catena, Alaz Özcan, +80

Nature Cancer

Clonal fitness inferred from time-series modelling of single-cell cancer genomes

Sohrab Salehi, Farhia Kabeer, Nicholas Ceglia, +103

Nature

Clonal FitnessFunctional GenomicsTumor HeterogeneityMedicineGenetics +10