One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4<i>H</i>-chromenes: Discovery of a Type of Potent Antibacterial Agent

Gen Zhang, Yaohu Zhang, Jiexi Yan, +4

The Journal of Organic Chemistry

Combinatorial ChemistryBioorganic ChemistryOrganic ChemistryFunction-oriented DesignChemistry +18

Antitumor effects, cell selectivity and structure–activity relationship of a novel antimicrobial peptide polybia-MPI

Kairong Wang, Bangzhi Zhang, Wei Zhang, +3

Peptides

Structure–activity RelationshipAntimicrobial Drug DiscoveryBiochemistryMedicineCell Selectivity +10

Two Hits Are Better than One: Membrane-Active and DNA Binding-Related Double-Action Mechanism of NK-18, a Novel Antimicrobial Peptide Derived from Mammalian NK-Lysin

Jiexi Yan, Kairong Wang, Wen Dang, +5

Antimicrobial Agents and Chemotherapy

Peptide LibraryPeptide EngineeringImmunologyAntiviral ResponseEscherichia Coli +12

A new rhodamine-based single molecule multianalyte (Cu2+, Hg2+) sensor and its application in the biological system

Lina Wang, Jiexi Yan, Wenwu Qin, +2

Dyes and Pigments

EngineeringBiosensing SystemsBioanalysisBiological SystemAnalytical Chemistry +7

Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells

Kairong Wang, Jiexi Yan, Bangzhi Zhang, +3

Cancer Letters

MedicineDrug DiscoveryNovel Antimicrobial PeptidePeptide LibraryCombination Therapy +7

A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice

Wei Zhang, Jia Li, Liwei Liu, +6

Peptides

Novel AnalogBiochemistryThioamide Bond SubstitutionMedicineAntimicrobial Peptide Polybia-mpi +9

Dual antifungal properties of cationic antimicrobial peptides polybia-MPI: Membrane integrity disruption and inhibition of biofilm formation

Kairong Wang, Jiexi Yan, Wen Dang, +11

Peptides

BiofilmsAntifungal AgentAntimicrobial SusceptibilityBiofilm FormationMembrane Integrity Disruption +7

The m6A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis

Yongqiang Zhou, Jiexi Yan, He Huang, +8

Cell Death and Disease

Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide

Jiexi Yan, Kairong Wang, Ru Chen, +5

Biochimie

MedicinePeptide LibraryImmunologyAntimicrobial ChemotherapyAntimicrobial Compound +2

Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista

Kairong Wang, Jiexi Yan, Ru Chen, +5

Antimicrobial Agents and Chemotherapy