Barry S. Goggin

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

Eli M. Wallace, James P. Rizzi, Guangzhou Han et al. · Cancer Research · 2016 · 329 citations

Medicine, Oncology, Pharmacology +17

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (<i>S</i>)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1<i>H</i>-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

Paul M. Wehn, James P. Rizzi, Darryl D. Dixon et al. · Journal of Medicinal Chemistry · 2018 · 114 citations · Full text

Medicine, Medicinal Chemistry, Oncology +15

The structure of XIAP BIR2: understanding the selectivity of the BIR domains

Christine Lukacs, Charles Belunis, R. Crowther et al. · Acta Crystallographica Section D Biological Crystallography · 2013 · 39 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain

Robert F. Kester, Andrew F. Donnell, Yan Lou et al. · Journal of Medicinal Chemistry · 2013 · 38 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Benzazepinones and Benzoxazepinones as Antagonists of Inhibitor of Apoptosis Proteins (IAPs) Selective for the Second Baculovirus IAP Repeat (BIR2) Domain

Andrew F. Donnell, Christophe Michoud, Kenneth C. Rupert et al. · Journal of Medicinal Chemistry · 2013 · 28 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15