Jessica J. Pfannenstiel

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice

Yousef M. Alhammad, Srivatsan Parthasarathy, Roshan Ghimire et al. · Proceedings of the National Academy of Sciences · 2023 · 58 citations · Full text

Viral Replication, Stark Reduction, Viral Polymerase Mechanism +19

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

Courtney E. Comar, Clayton J. Otter, Jessica J. Pfannenstiel et al. · Proceedings of the National Academy of Sciences · 2022 · 51 citations · Full text

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

Clayton J. Otter, Nicole Bracci, Nicholas A. Parenti et al. · Proceedings of the National Academy of Sciences · 2024 · 41 citations · Full text

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner

Catherine M. Kerr, Srivatsan Parthasarathy, Nancy Schwarting et al. · Journal of Virology · 2023 · 22 citations · Full text

Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target

Sarah Wazir, Tomi A. O. Parviainen, Jessica J. Pfannenstiel et al. · Journal of Medicinal Chemistry · 2024 · 17 citations · Full text