A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis

Daniel Ajona, Sergio Ortiz‐Espinosa, Haritz Moreno, +10

Cancer Discovery

ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours

Silvestre Vicent, José M. López-Picazo, Gemma Toledo, +8

British Journal of Cancer

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

Adrián Vallejo, Naiara Perurena, Elizabeth Guruceaga, +20

Nature Communications

Elevated NSD3 histone methylation activity drives squamous cell lung cancer

Gang Yuan, Natasha Flores, Simone Hausmann, +19

Nature

Histone ModificationsTumor BiologyChromatinMedicineEpigenetic Change +11

Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models

Silvestre Vicent, Chen Ron, Leanne C. Sayles, +11

Journal of Clinical Investigation

Oncogenic KrasDevelopmental BiologyWt1 InactivationMedicineWt1 Loss +13

Mitogen-Activated Protein Kinase Phosphatase-1 Is Overexpressed in Non-Small Cell Lung Cancer and Is an Independent Predictor of Outcome in Patients

Silvestre Vicent, Mercedes Garayoa, José M. López-Picazo, +4

Clinical Cancer Research

Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade

Daniel Ajona, Sergio Ortiz‐Espinosa, Teresa Lozano, +21

Nature Cancer

Lung TumorsMedicineImmunologyBronchial NeoplasmImmune Checkpoint Inhibitor +4

A Novel Lung Cancer Signature Mediates Metastatic Bone Colonization by a Dual Mechanism

Silvestre Vicent, Diego Luis-Ravelo, Iker Antón, +5

Cancer Research

Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis

Sergio Ortiz‐Espinosa, Xabier Morales, Yaiza Senent, +28

Cancer Letters

InflammationCytokineComplement SystemNeutrophil Extracellular TrapsGranulocyte +8

Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects

Daniel Ajona, Carolina Zandueta, Leticia Corrales, +12

American Journal of Respiratory and Critical Care Medicine