Randolph Ponticiello

Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in <i>db/db</i> Mice

Thomas Harrity, Dennis Farrelly, Aaron Tieman et al. · Diabetes · 2006 · 80 citations · Full text

Ppar Target Genes, Immunology, Pharmacotherapy +19

Discovery of 5-Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1<i>H</i>)-one (BMS-903452), an Antidiabetic Clinical Candidate Targeting GPR119

Dean A. Wacker, Ying Wang, Matthias Broekema et al. · Journal of Medicinal Chemistry · 2014 · 45 citations · Full text

Pharmaceutical Science, G-protein-coupled Receptor 119, Pharmacotherapy +17

Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1)

Shung Wu, David Yoon, Janice E. Chin et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 27 citations · Full text

Medicinal Chemistry, Human 11β-Hydroxydehydrogenase 1, Biochemistry +7

Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)

Jun Li, Lawrence J. Kennedy, Haixia Wang et al. · ACS Medicinal Chemistry Letters · 2014 · 22 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +15

The Dual Peroxisome Proliferator-Activated Receptor α/γ Activator Muraglitazar Prevents the Natural Progression of Diabetes in db/db Mice

Effie Tozzo, Randolph Ponticiello, Joann Swartz et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 17 citations