HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Nourdine Hamdane, Frank Jühling, Émilie Crouchet, +32

Gastroenterology

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease

Naoto Fujiwara, Naoto Kubota, Émilie Crouchet, +38

Science Translational Medicine

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, +12

Journal of Virology

Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma

Frank Jühling, Nourdine Hamdane, Émilie Crouchet, +29

Gut

Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies

Catherine Fauvelle, Daniel J. Felmlee, Émilie Crouchet, +16

Gastroenterology

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

Éloi R. Verrier, Amélie Weiss, C Bach, +13

Gut

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Natascha Roehlen, Antonio Saviano, Houssein El Saghire, +43

Science Translational Medicine

ImmunologyPathologyCholangiopathiesCellular PhysiologyInflammation +18

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Éloi R. Verrier, Che C. Colpitts, C Bach, +14

Cell Reports

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Émilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, +62

Nature Communications

Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment

Natascha Roehlen, Marion Müller, Zeina Nehme, +39

Journal of Hepatology

Claudin-1-specific AntibodiesOncogenic AgentCarcinogenic SignalingImmunologyPathology +3